Lymphadenopathy refers to the enlargement of one or more lymph nodes, which are small, bean-shaped structures that help filter lymph fluid and support the immune system. This condition can result from infections, inflammatory diseases, or malignancies. Lymphadenopathy may be localized (affecting a specific area) or generalized (involving multiple regions of the body). Enlarged lymph nodes may feel tender, firm, or mobile depending on the underlying cause. Evaluation typically involves physical examination, medical history, and, if needed, imaging or biopsy to determine the cause and guide treatment.